I have no comment really on the strength aspect, just always heard they'll handle more power reliably.
The biggest thing I see is gear ratios. Once you make 1,000+ HP (especially on a small tire), you need a lot less starting line ratio. Not many options w/ a 727.


CHIP
'70 hemicuda, 575" Hemi, 727, Dana 60
'69 road runner, 440-6, 18 spline 4 speed, Dana 60
'71 Demon, 340, low gear 904, 8.75
'73 Chrysler New Yorker, 440, 727, 8.75
'90 Chevy 454SS Silverado, 476" BBC, TH400, 14 bolt
'06 GMC 2500HD LBZ Duramax