Would love to test it on an engine with 8 EGT's, but looking at the overhead shot of both makes it seem like the mixture distribution wouldn't be as even on the 4500 flange version, a disproportionate amount of the throttle blade looks to favor 1, 7, 2 and 8. I'd expect cylinder to cylinder variation that would be partially resolved with the smaller opening. With EFI you can fix some of that distribution with individual cylinder timing and fuel trims, but you can't fix lower output from less air physically in the cylinder.