I did a 427 inch SB once using a 4.125 crank with small journal chevy rods. Things were very close. The windage tray had to be modified, we tried several different oil pickup tubes before finding one that worked, etc. Hughes might still sell their stroker kit with the 4.180 stroke and Honda journals. That combo might clear things a little better. I'm not so sure I'd try the 4.250 combo unless I had a lot of time and patience.