The 374 I just sold was a 4in bored 08 block(with a modified 6.4 crank)
I' ve gone as big as 4.09 but that block's original bores were spot on center to start with, but I've had one crack @ 4.08

I wouldn't fear taking any 03-08 5.7 block out to 4in
Anything over 4.0 have it sonic checked and go from there.
Arrington has been doing 4in bore block builds for a few years now, and Nutter racing has been doing 6.1 4.055 bore) 5.7s .My niece Caroline's 05 300srt daily has had 370(4.055) bore 5.7 in it since 08,one of her late boyfriend's 1st builds 10 years and over 140k on that engine, and she's not nice to it.
Attached (only ment to attach 1 photo) is a cross cut of an 05 5.7 block that was stock bore, it's a THICK bore for the record it measures out to be .034-.04
The Eagle blocks are only good for a .03 over bore