I've put my 451 together with that cam and hand-ported iron heads. My block did not need any machining. I've read that if you float the valves you could be in big trouble because the lifter will smack the underside of the lifter bore area and could break something if there is not a smooth back-spotfaced area for it to hit.
I'd be ecstatic with 10's of any kind! As I posted elsewhere this is a used set and I'm getting more nervous as startup time approaches. I think I'll pull it out and buy a brand new cam/lifters if I can find the B/RB package (P3690588).
The question that comes to mind is, are you trying to achieve something that you don't feel you could do with a traditional flat tappet cam?
More lift with a given duration compared to most solid cams. Although more modern grinds with higher lift rates are available nowadays, I would be less concerned about lifter wear on a 1.00" mushroom compared to the standard .904" diameter.
