Google 12 valve performance paths, you will find a bunch of write ups on several forums. That is the best way to do it. Start with maintenance items first, then guages. Your weak link is the auto trans, those don't work from the factory so expect to spend $3-5k on a trans first
I have a 95 12 valve nv4500 in a 90 Ford F350 my fuel plate is slid forward and I have Bosch 250 or 275 injectors (can't remember) a long time. In this trim I 30PSI of boost and can haul 10k up a hill in 4th gear at speed.