The compression is comically low.

I can't find the cam card, but I had a 78 400 in a 4 door with a cam very similar to this:

http://www.compcams.com/Company/CC/cam-specs/Details.aspx?csid=707&sb=2

With highway gears and dual exhaust (2.25" with H), the hi-po manifolds, here you can see for yourself it ran well.

https://www.youtube.com/watch?v=cTizSWTZxGo

About a 4400 lb car, doubt an earlier C body is much heavier or even as heavy. The smog heads suck, but they don't flow any less than a "HP" 440 head. About 200 cfm.

You might think this to be a little radical on a heavy car with low compression, but I found it worked pretty well with a dual plane intake (and thermoquad). The last thing I would ever suggest is that you go with a single plane intake with that setup. I tried it. Upper end was good, but it was a dog out of the hole