Few years back I made some changes and will post the results, but I had several variables thrown in the mix. 70 Duster.

I went from a 416 to a 422. both were run in the same car, with same heads, headers, intake, carb, convertor and transmission. Did swap from Erson rocker gear to Jesel.

There were two differences, went from a 260/266 600 lift flat tappet, to a 273/280 700 lift roller. The other change was going from about 11.5 compression to 13.3 compression.

Car went from best of 10.38 at 128 and change, to 9.85 at almost 135.
This was using w5 heads. I know the roller helped a good bit but I feel like the compression did as well. Unsure if going from the 4.07 bore 416 to the 4.100 bore 422 impacted things much at all.

I noticed the convertor( same one for both, never had it re adjusted) went from flashing 5200 ish to about 5500.

The new owner has now bumped the compression up past 14 to 1, run a more aggressive lobe roller that is about 276@50, and taken about 100 pounds out of the car( he is 100 pounds smaller than me..lol)
And has now been 9.62 at almost 140. So cam and compression keep picking the car up, the 100 pounds doesn't account for the almost 5mph gain he has seen.

The OP is a whole lot smarter than me, but my guess is throwing camshaft at the car in correct tandem with more compression and a workable convertor will show gains, but likely diminishing as you get compression way up there.