If it's been maintained well, then not really.

Ball joints, trac-bars, and wheel bearings are all the weak link in the front end. The 24V engines don't have the injector problems that the newer trucks do, but they are extremely prone to failing lift pumps which will take out the injection pump. That's about a $1500 hit right there by the time you buy a lift pump, injection pump, and a gauge or light to monitor your fuel pressure and help prevent future problems.

Automatics are weak, but can be built into a very stout unit. At stock power levels the 6-speeds are fairly bulletproof. Run a good synthetic fluid and over fill them by a couple quarts more than the recommended capacity and they'll last forever. 5-speeds are decent, but prone to 5th gear nut backing out. Relatively simple fix though.