We run the 2" Hooker Fender Well Headers, and the 26" tire. Like everyone else has indicated, the headers rub the tires when you turn, especially to the left.
However, another concern that I didn't see mentioned is that the collectors hang at such an angle that you must be careful unloading your car from the trailer, because the flang, particularly the drivers side, can hang up on your ramp or the back of the trailer.
In addition we run race mufflers with turn outs on ours and they can be a little low as well.