A 4.350 bore in a stock block with a 4.5 stroke yields 535 cubes and ported 906 or other stock heads produces a BUNDLE of torque. Keep the cam duration some where between the specs for a 528 lift Mopar cam or a bit more. The reason being that ANDYF Tried a lot of cams and stock exhaust manifolds and bigger cams just flat didn't work with mainfolds and mufflers.
Keep the rotating assembly as light as you can to save bob wieght. .990 pins, 2.2 journal 7.10 rods, and the lightest piston they will make will allow a safe margin for a motor with stock caps up to about 5500 rpm. I ran a stock block with 6 pak rods, 4.5 stroke with stock main caps and the block lived right up till the used crank I had in it broke. (it was cracked when we built the motor) I got a lot of use out of the motor, racing it for years making 650 hp and going as high as 6200 rpm at the end with a big roller cam. So I don't see an issue with a properly built torque type street stroker motor.