Depends on the hp you want to make. First motor Dad and I built was completely stock with a good head and it ran 6.30-6.40's in the 1/8 on 13-14# of boost in a 2315# car.
Check out some of the build threads on slantsix.org and that should give you a good start.
"Turbo will be easiest, and at the HP level will also be easiest on parts. Spend the money to do it right, and you can build a 500 HP street motor that will live a long and happy life, and probably with a very basic short block."
Those words must have left a bad taste in his mouth!
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