I don't think the question has enough info, application, etc. And although I don't think it is a good idea for most applications, you can with enough effort and risk go pretty big.

I like the 4.250" stroke combos in the low deck. They fit nice with 6.535" long connecting rods and with a 4.375-4.380" bore, 511-512 CID is a nice motor.

I am sure you can fit a 4.50" stroke into the thing, but I don't like it. That would be 540ish CID with the limitations on bore with a stock block.

1993 Daytona, 5.50 at 130mph (1/8) 1.19 sixty ft (PG). Link to 572 B1 - Part 1