I've seen several factory setups (mostly GMs and Harleys) over the years where the MC that were run at a slight angle so it really shouldn't be a problem as long inlet holes are contiounsly covered with fluid.

1957 Plymouth (Hemi, Dual Quads, A833 4 Speed 9 1/4 w 4.10) Sold
1937 Dodge Pickup (Hemi, 6X2 intake, 46RH, Dana 60 w 4.56) Sold
1968 Plymouth Valiant 2dr sedan (354 HEMI, 46RH w/4.30 gears) under construction