I would verify the actual, not factory specs,. true compression ratio that motor actually has and go from there. Aren't all the 6.1 Hemi 10.0 to 1 or more stock?
The last pump gas street Hemi motor I built for a customer had right at 9.3 to 1 true mechanical compression ratio, it had a Litlefield 10:71 roots blower on it with two Carb Shop built Dominatoer carbs that were around 1050 CFM at 28.5 inches. That motor 927 HP at 7300 RPM with CA pump swill at 7.5 lbs. of boost at 12.0 percent underdriven with 33 degrees total timing using a MSD 7AL2 ignition, we switch the pulleys which made it have 13 percent overdrive and we retarded the timing to 25 degrees BTDC total and swap to Union 76 race gas with 116 octane and that motor made 1027 HP at 6500 RPM with 12.0 lbs. boost before starting to detonate and miss
My point is that motor drove on the street a lot better than another pump gas blown Hemi motor for another customer that had less compression ratio and sped up the blower to make more power on the street.
Most street driving is around or under 2500 RPM in town at light part throttle so that makes the low RPM throttle response important