back in my junkyard days, i had a 73 4x4 that had 3.91 gears, 32" tires, and a 318/727 combo.
when i replaced the bed, i built one from 1/8" plate with a 2x12 oak floor. this bed was to be indestructible when hauling parts and scrap. [it turned out to be, as 40yrs later, the buyer of my truck still owns it, and the bed is still as i built it.
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when it was done and installed, along with a "basher bumper" and bed roll bar made from 3" gas line piping, [not the cheapo thin items you buy on the market today, as well as back then] the truck weighed over 7000lbs.
the 318 never got any gas mileage as it was, and after the mods, it got around 5mpg.
i grabbed a 440/727 out of a chrysler station wagon, tore the 318's 727 apart for the short tailshaft stuff [the truck had a divorced transfer case] and stuffed it in my truck.
the only mods to the station wagon engine was an rv cam, and an 850cfm T-quad with an adapter to the square bore intake the station wagon engine came with. [i think the wagon was a 69 or 70 model.]
the gas mileage went instantly from 5 to 14 or so empty, to 10-12 when loaded with parts or scrap. the owner today [who bought my truck all those years ago] still says the truck gets amazing gas mileage !
i think the reason was the 440 just loafs along pulling that weight, while the 318 was foot to the floor most of the time.
just my personal experience with a 440 in a truck. your mileage will vary.