bleed down on lifters will reduce compression test. I use performance trend engine analyzer software, it will calculate cranking compression, generate an advance curve, tell you if detonation is an issue with different octane fuels, idle vacuum, besides HP and torque. I never build an engine without running it through the program. But like any program you have to take the time to put good numbers in it. Things like really knowing what your static compression is, intake and header lengths, flow of your heads, etc.
The higher the cranking compression the more power an engine makes, unless detonation becomes an issue.

If there's no problem knocking then it is what it is. I use compression MAINLY to gage overall ring and valveseal etc and only get concerned if there's a major disparity from cylinder to cylinder. Or if it's much different than the day it was built.

With the bleed rates that most aftermarket HR lifters have, combined with the elevated spring loads most of the associated cams require....... I’d expect the lifters are substantially bled down, which shortens the cam timing during the cranking pressure test, which gives a higher number than what the true dynamic CR would be with the motor running and the lifters pumped up.

It’s like an extreme example of the principle behind Rhodes Lifters.

If one was curious what the difference might be, they could bottom the lifter plungers out on one cylinder, and see how that impacted the cranking pressure results.