Whats a good jetting point for s 500 ci
Wedge with indy Sr heads 640 lift roller cam 12 .I compression with tunnelram and twin 850 double pumper

That is a big question. Start with factory settings, take out the powervalves, jet up 4 numbers on the blocks you took the power valves out of and then it is start with reading plugs and O2's if you have them. I just did a tunnel ram with twin dominators they came in at 6 numbers leaner than stock.

I have a twin Dominators set up also that I drive on the street. Mine are staggered from 88's to 91's I believe. I have O2's and all 8 EGT's also which helps. Obviously, no where near stock.... lol. It is fat at idle but cleans up and has perfect AFR's at cruise and WOT.

Why not cleanup the idle circuits?
Make a idle mixture screws adjustment or enlarge the idle bleed holes on top of the carb main body

It's not pig fat. Doesn't smell or water your eyes or anything. It is 10.5-11.0 on the O2's at idle and 13.0-13.7 at idle and WOT.

I shoot for between 14.2 to 15.3 AFR at idle and shoot for 13,6 to 14.5 AFR at light part throttle driving under 2300 RPM at operating temps, 12.3 to 13.6 AFR at WOT when racing, depending on pump gas or which fuel is being used to get the best MPH in the 1/4 mile , not E 85 though

With this car driving back and forth to work it's not very gas mileage friendly anyway.... lol. The 2 kits Come in handy if I am running late.

Listen to Cab.

Perhaps also reduce fuel to the idle transfer slots via smaller jets if the metering block/body allows it or mod the block/body to enable you to do so.

Then tune with IABs etc to clean up the idle even better.

Even with a .750 lift roller I'm in the low - mid 15s at idle, and similar numbers to Cabs cruise and WOT numbers.

Engine loves it

I appreciate the input and help guys. It rev's like a small block and runs exceptionally well as is but a little more fine tuning won't hurt. Mine is over .800 solid roller. Makes great power to 7600.