/5000 hp what kind of car is it in ?? our door slammer [ promod] has a screw blown hemi thats around 3500 hp we take 1000 hp out to get it to move off the starting line 5.66 at 259 mph 1/4 3.67 at 208 in the 1/8

Still loving mine after 10 years. Started with blow through, premium pump gas, and a 180K mile,8:0-1 compression, 383 with up to 15 lbs. Learned a lot with the "expendable" engine.#1 takeaway is to bullet proof your boost control devices. A melted W.G.. reference line, or a stuck wastegate will likely cost you at least a head gasket (or 2).Cheap blue Fel-pro gaskets make a great "Fuse".#2, don't get greedy with the timing. Stock junk will live -IF- you don't rattle it. I'm running 20 degrees total timing. I currently have the Sniper X-flow running pump E-85 on a 10:0-1 470 with two of the "Hong Kong Hurricane" 69 m,m, ebay turbos. Got a home made girdle, B.B.C. Eagle rods ,K.B. Icon pistons ,and haven't hurt the bottom end yet. Had it up to 17 lbs. with E-85 and the blow through carb. Got to the point where it couldn't get enough fuel through the "gas" downleg boosters ,so I decided to go to E.F.I. At just 12 lbs. it's uncontrollable below 60 m.p.h. Has 315-60 M/T drag radials, Cal track bars, Cal track shocks, 90/10 front shocks, and the traction gods don't care, but it is a blast to drive .I should add some safety equipment so i can take it to the track. I believe the old 383 would live forever with a 5500 r.p.m. shift point and 15 lbs. Don't be afraid to lean on the stock parts.

The big advantage to boost... since power can be produced at far lower RPM* than NA, you don't need $4,000 rocker arms, fabricated intake manifolds, stepped-tuned headers,1,000 lb. use-it-50-times-and-throw-it-away valve springs, $$$ connecting rods, and billet cranks.
How to tell which common engines work well with boost (produce X power from Y inches @ Z boost)? Everything produces more power with boost, but is there a reliable predictor for "if it does this at ATM it will do that @ 40 psi"? No. Port flow CFM and valve area per cubic inch, rod ratio are all factors but none are linear.
What to do? Use what everyone else uses (LS, BBC, Gen-2 hemi), or you're stepping way out on thin ice. Some untested engines may surprise you (how about the 289 Studebaker?), but others will produce hundreds of HP less than those mentioned at the same boost level.



* 8,000 RPM is not 33% more inertial load than 6,000 (8K ÷ 6K = 1.333), but 78% (8K^2 ÷ 6K^2 = 1.778).

The big advantage to boost... since power can be produced at far lower RPM* than NA, you don't need $4,000 rocker arms, fabricated intake manifolds, stepped-tuned headers,1,000 lb. use-it-50-times-and-throw-it-away valve springs, $$$ connecting rods, and billet cranks.
How to tell which common engines work well with boost (produce X power from Y inches @ Z boost)? Everything produces more power with boost, but is there a reliable predictor for "if it does this at ATM it will do that @ 40 psi"? No. Port flow CFM and valve area per cubic inch, rod ratio are all factors but none are linear.
What to do? Use what everyone else uses (LS, BBC, Gen-2 hemi), or you're stepping way out on thin ice. Some untested engines may surprise you (how about the 289 Studebaker?), but others will produce hundreds of HP less than those mentioned at the same boost level.

* 8,000 RPM is not 33% more inertial load than 6,000 (8K ÷ 6K = 1.333), but 78% (8K^2 ÷ 6K^2 = 1.778).

Kind of off topic a little but a couple of ?......what mph are you pushing ? Is that 500"in a stock block? And how is that hood holding up?