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Re: The official Coronavirus thread [Re: 360view] #2835427
10/21/20 05:35 AM
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Mild symptom Covid sheds virus for about 9-10 days.
Severe symptom Covid sheds virus for 20+ days

https://medicalxpress.com/news/2020-10-evidence-cdc-guidance-infectivity-coronavirus.html

Re: The official Coronavirus thread [Re: 360view] #2835428
10/21/20 05:37 AM
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Re: The official Coronavirus thread [Re: 360view] #2835432
10/21/20 05:51 AM
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Researchers claim to have made breakthrough in how Covid infects cells

https://medicalxpress.com/news/2020-10-neuropilin-sars-cov-infectivity-breakthrough.html

Sample quote

Yohei, Boris and Pete explained: "In looking at the sequence of the SARS-CoV-2 Spike protein we were struck by the presence of a small sequence of amino acids that appeared to mimic a protein sequence found in human proteins which interact with neuropilin-1. This led us to propose a simple hypothesis: could the Spike protein of SARS-CoV-2 associate with neuropilin-1 to aid viral infection of human cells? Excitingly, in applying a range of structural and biochemical approaches we have been able to establish that the Spike protein of SARS-CoV-2 does indeed bind to neuropilin-1.
...snip...
Intriguingly, scientists at the Technical University of Munich, Germany and the University of Helsinki, Finland, have independently found that neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity.

Together the Bristol researchers concluded: "To defeat COVID-19 we will be relying on an effective vaccine and an arsenal of anti-viral therapeutics. Our discovery of the binding of the SARS-CoV-2 Spike to neuropilin-1 and its importance for viral infectivity provides a previously unrecognised avenue for anti-viral therapies to curb the current COVID-19 pandemic."

End quote

Re: The official Coronavirus thread [Re: 360view] #2835698
10/21/20 02:59 PM
10/21/20 02:59 PM
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Originally Posted by 360view
Excess deaths graphed

https://medicalxpress.com/news/2020-10-total-deaths-pandemic-attributed-covid-.html

Sample quote

For every two deaths attributed to COVID-19 in the U.S., a third American dies as a result of the pandemic, according to new data publishing Oct. 12 in the Journal of the American Medical Association.

The study, led by researchers at Virginia Commonwealth University, shows that deaths between March 1 and Aug. 1 increased 20% compared to previous years—maybe not surprising in a pandemic. But deaths attributed to COVID-19 only accounted for 67% of those deaths.
..snip..
For example, the study specifically showed that the entire nation experienced significant increases in deaths from dementia and heart disease. Woolf said deaths from Alzheimer's disease and dementia increased not only in March and April, when the pandemic began, but again in June and July when the COVID-19 surge in the Sun Belt occurred.

End quote

In the US there were under mean deaths since the 2017 increase from influenza. This may have left many elderly and susceptible to death and resulted in the surge in March-May. If you look at the CDC all cause deaths in Aug-Sep they are running under mean again. An increase in cases hasnt increased deaths. This phenomena also happened in Nordic countries including Sweden. THey are having single digit daily deaths now, as is my state.

Re: The official Coronavirus thread [Re: 360view] #2836130
10/22/20 01:51 PM
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Taiwan versus New Zealand Covid response:

https://medicalxpress.com/news/2020-10-covid-world-nz-taiwan.html

Sample quote

The lead author of the research paper, Dr. Jennifer Summers, from the University of Otago, Wellington, says the two countries used different approaches to respond to their first waves of COVID-19.

Taiwan acted very early to control the virus, introducing health screening of air passengers on the day the World Health Organization was informed of the outbreak in Wuhan on 31 December 2019.

"Despite Taiwan's closer proximity to Wuhan and its high population density it experienced a substantially lower incidence rate of 20.7 cases per million compared with New Zealand's 278 per million. Their timely and vigorous response allowed Taiwan to avoid the national lockdown used in New Zealand to eliminate community transmission."

In both countries, outbreaks of COVID-19 prompted public health officials to introduce a range of measures including contact tracing, testing and isolating of cases and quarantine of close contacts.

Fellow author Professor Michael Baker from the University of Otago, Wellington, says Taiwan benefited by having a Centers for Disease Control in place, as well as a National Health Command Center dedicated to responding to emerging threats such as pandemics. Because of historically low levels of investment in public health, New Zealand was forced to take a more reactive approach to the pandemic with a stringent national lockdown to eliminate COVID-19 transmission while essential response capacities were rapidly developed.

"Taiwan's pandemic response had been extensively planned, partly as a result of their experience in the SARS pandemic in 2003, and was set up so it could be rapidly adapted to new pathogens. As in many Asian countries that had experiences with SARS, Taiwan had an established culture of face mask use by the public, as well as a proactive policy of supporting production and distribution of masks to all residents."

Both countries provided social and financial support during the pandemic and have existing universal health coverage.

End quote

Re: The official Coronavirus thread [Re: 360view] #2836144
10/22/20 02:27 PM
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Just thinking out load, I wonder knowing what we know today, what would have been the outcome (virus/health/economic, etc) today, if we had say on 3/15/20 (?, pick a day) the US had done a full, unprecedented ( and maybe unconstitutional?) across the board, near maximum lock down/quarantine?


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Re: The official Coronavirus thread [Re: 360view] #2836182
10/22/20 03:37 PM
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Moderna vaccine trial reaches its 30,000 volunteer goal ahead of schedule

https://www.cnn.com/2020/10/22/health/moderna-covid-19-vaccine-trial-30000-participants/index.html

Sample quote

Hoge said three things needs to happen before Moderna applies to the FDA for emergency use authorization.

Of the 30,000 participants, 53 need to become sick with Covid-19. The company expects that to happen in the second half of November.

The second milestone is that of the 53 participants who become ill with Covid-19, at least 40 of them need to be participants who received the placebo. That would show the vaccine is 75% effective.

The third milestone is a requirement by the FDA to ensure that enough time has passed to see if participants develop side effects.
The FDA rule is that at least eight weeks must pass after half the participants have received their second shot before a company can apply for emergency use authorization.

End quote

Re: The official Coronavirus thread [Re: 360view] #2836188
10/22/20 03:59 PM
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Daily 81 mg aspirin trial in hospitalized Covid patients significantly reduces risks

https://medicalxpress.com/news/2020-10-aspirin-death-hospitalized-patients.html

Sample quote

To conduct the study, Dr. Chow and his colleagues culled through the medical records of 412 COVID-19 patients, age of 55 on average, who were hospitalized over the past few months due to complications of their infection. They were treated at the University of Maryland Medical Center in Baltimore and three other hospitals along the East Coast. About a quarter of the patients were taking a daily low-dose aspirin (usually 81 milligrams) before they were admitted or right after admission to manage their cardiovascular disease.

The researchers found aspirin use was associated with a
44 percent reduction in the risk of being put on a mechanical ventilator,
a 43 percent decrease in the risk of ICU admission
and—most importantly—
a 47 percent decrease in the risk of dying in the hospital compared to those who were not taking aspirin.
The patients in the aspirin group did not experience a significant increase in adverse events such as major bleeding while hospitalized.

End quote

Re: The official Coronavirus thread [Re: 360view] #2836367
10/23/20 06:03 AM
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Sweden continues its approach to Covid despite rise in mostly non-fatal cases since September

https://medicalxpress.com/news/2020-10-sweden-guns-covid-cases.html

Sample quote

On Thursday the country also introduced restrictions on nightclubs, with Prime Minister Stefan Lofven admonishing Swedes "that the party is over now in nightclubs, and it needs to stay that way for as long as necessary".

Yet Sweden remains one of the only countries in the world that still does not recommend face masks, arguing they provide a false sense of security that undermines social distancing efforts.

Life goes on

In the capital Stockholm, daily life appears to carry on almost as normal, as locals stroll through the city bundled up against the chilly autumn weather and stopping in at cafes, restaurants and shops that have remained open throughout the pandemic.

And while images in the media occasionally show crowded city buses and restaurants, surveys by the Swedish Civil Contingencies Agency found that 80 percent of Swedes have changed their behaviour as a result of recommendations.

They are working from home or limiting social contacts—even though there are no fines or sanctions for disregarding them.
...snip...
On Thursday, the government also lifted its special recommendation in place since April for people over the age of 70 and risk groups to shield themselves.

There were concerns the measure was isolating them too much and leading to other public health issues like depression and loneliness.

Those groups had been urged to avoid shops, public transport and any place where groups of people gather.

Earlier this month, the government also lifted its ban on visits to nursing homes—one of the rare restrictions introduced during the pandemic.

End quote

Re: The official Coronavirus thread [Re: 360view] #2837625
10/26/20 02:55 PM
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Danish researchers say they did a careful study about the effectiveness of wearing masks,
but now cannot find a journal “brave enough” to publish it.

https://justthenews.com/politics-po...iple-journals-amid-rumors-it-shows-masks

Sample quote

A 2019 World Health Organization review of pandemic mitigation measures, for instance, found "no evidence" that face coverings helped to stop the spread of influenza.

Whether or not studies on influenza transmission can apply to COVID-19 is unknown; the disease's relatively recent emergence means that scientific studies on it are in short supply. Studies can take many month to secure funding, develop methodologies, carry out experiments, interpret the findings, write a research paper and get it peer-reviewed and published.

To bridge that gap, a team of Danish scientists earlier this year sought to carry out a major randomized controlled trial study to determine how effective masks might be at stopping COVID transmission. The study, begun in April, involved around 6,000 Danish citizens, half of whom wore face coverings during "normal behavior" and the other half of whom went without them.

The study concluded in June. Yet the Copenhagen newspaper Berlingske reported this week that it has been rejected by at least three elite medical journals so far — the Lancet, the New England Journal of Medicine, and JAMA, the Journal of the American Medical Association.

"They all said no," Christian Torp-Pederson, one of the study's researchers, told the Danish newspaper this week. He added that the study's scientists "cannot start discussing what [the journals] are dissatisfied with, because in that case we must also explain what the study showed, and we do not want to discuss that until it is published."

End quote

Re: The official Coronavirus thread [Re: 360view] #2837982
10/27/20 12:27 PM
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British find that their death rate for severe Covid has dropped 50%

https://medicalxpress.com/news/2020-10-death-people-severe-covid-england.html

Re: The official Coronavirus thread [Re: 360view] #2837984
10/27/20 12:29 PM
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Spanish report that 80% of their severe Covid patients have low Vitamin D

https://medicalxpress.com/news/2020-10-covid-patients-vitamin-d-deficiency.html

Re: The official Coronavirus thread [Re: 360view] #2838037
10/27/20 03:07 PM
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First T-Cell transfusion treatment for Covid-19

https://www.news-medical.net/news/2...ect-vulnerable-people-from-COVID-19.aspx

Sample quote

T-cells taken from the blood of people who recovered from a COVID-19 infection can be successfully multiplied in the lab and maintain the ability to effectively target proteins that are key to the virus's function, according to a new study published Oct. 26 in Blood.

"We found that many people who recover from COVID-19 have T-cells that recognize and target viral proteins of SARS-CoV-2, giving them immunity from the virus because those T-cells are primed to fight it," says Michael Keller, M.D., a pediatric immunology specialist at Children's National Hospital, who led the study.

"This suggests that adoptive immunotherapy using convalescent T-cells to target these regions of the virus may be an effective way to protect vulnerable people, especially those with compromised immune systems due to cancer therapy or transplantation."
End quote

Re: The official Coronavirus thread [Re: 360view] #2838039
10/27/20 03:12 PM
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Nasal spray formulation of ivermectin for COVID-19 shows promise in pigs

https://www.news-medical.net/news/2...-for-COVID-19-shows-promise-in-pigs.aspx

Re: The official Coronavirus thread [Re: 360view] #2838086
10/27/20 05:34 PM
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Covid-19 can damage the frontal lobes of the brain, especially in males over age 61

https://medicalxpress.com/news/2020-10-eegs-covid-brain.html

Sample quote

Some of the EEG alterations found in COVID-19 patients may indicate damage to the brain that might not be able to be repaired after recovering from the disease.

"As we know, the brain is an organ that cannot regenerate, so if you have any damage it will more than likely be permanent or you will not fully recover," Haneef said.

Haneef found the location of the abnormal activity interesting.

"We know that the most likely entry point for the virus is the nose, so there seems to be a connection between the part of the brain that is located directly next to that entry point," he said. "Another interesting observation was that the average age of those affected was 61, one-third were female and two-thirds were males. This suggests that brain involvement in COVID-19 could be more common in older males. More research is needed but these findings show us these are areas to focus on as we move forward."

It may not always be the virus acting directly on the brain causing the abnormal EEG readings, Haneef said. It could be the oxygen intake, heart problems related to COVID-19 or another type of side effect, which is why he says that comprehensive patient care should include more imaging of the brain or EEG testing as necessary.

"These findings tell us that we need to try EEG on a wider range of patients, as well as other types of brain imaging, such as MRI or CT scans, that will give us a closer look at the frontal lobe," Haneef said. "A lot of people think they will get the illness, get well and everything will go back to normal, but these findings tell us that there might be long-term issues, which is something we have suspected and now we are finding more evidence to back that up."

End quote

Re: The official Coronavirus thread [Re: 360view] #2838413
10/28/20 03:30 PM
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Re: The official Coronavirus thread [Re: 360view] #2838416
10/28/20 03:32 PM
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Covid-19 antibodies last at least 5 months

https://medicalxpress.com/news/2020-10-people-mount-strong-antibody-response.html

Sample quote


"While some reports have come out saying antibodies to this virus go away quickly, we have found just the opposite—that more than 90 percent of people who were mildly or moderately ill produce an antibody response strong enough to neutralize the virus, and the response is maintained for many months," said Florian Krammer, Ph.D., Professor of Vaccinology at the Icahn School of Medicine at Mount Sinai and a senior author of the paper. "Uncovering the robustness of the antibody response to SARS-CoV-2, including its longevity and neutralizing effects, is critically important to enabling us to effectively monitor seroprevalence in communities and to determining the duration and levels of antibody that protect us from reinfection. This is essential for effective vaccine development."

Study findings are based on a dataset of 30,082 individuals, who were screened within the Mount Sinai Health System between March and October, 2020.

End quote

Re: The official Coronavirus thread [Re: 360view] #2838418
10/28/20 03:38 PM
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Covid caused loss of smell (and sore throat)
occurs much earlier than elevated temperature

https://medicalxpress.com/news/2020-10-loss-earlier-covid-symptom-fevera.html

Sample quote

A new analysis of coronavirus studies that involved Monell found that 77% of coronavirus patients had complete or partial loss of smell when tested. Forty-four percent were aware of the symptom without testing. Loss of sense of smell (along with sore throat) is also one of the earliest symptoms, making it more useful than later symptoms for protecting others from exposure, Rawson said.

"It is one of the earliest symptoms, and it is certainly earlier than fever," she said. "Smell loss alone predicts diagnosis better than a fever." Taste loss can occur as well, but it is less common and often related to smell loss.

Rawson's interest in what coronavirus does to the sense of smell—aka olfaction—goes well beyond its potential for screening. The pandemic, she said, could leave up to 750,000 Americans unable to smell, and that has major implications for their safety and quality of life.

She has been testing her own sense of smell each evening this month. She's participating in a pilot study of a new screening system that she hopes will lead to a large clinical trial. But the tests also ease her mind about allergy symptoms. She said a number of studies evaluating smell tests for coronavirus screening are in the works.

The trial Monell hopes will receive funding involves a smell test it developed called Scentinel.
The Philadelphia nonprofit partnered with Scentisphere to create the test,
which contains three peel-and-sniff films. Two have no scent. The third contains a rotating group of familiar odors like coffee, chocolate, popcorn, and natural gas. People who take the tests are asked to say which strip (if any) has a scent, rate its intensity, and identify the odor.

End quote

Re: The official Coronavirus thread [Re: 360view] #2838421
10/28/20 03:47 PM
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UNC researchers claim mouth is the infection entry point for Covid-19

https://medicalxpress.com/news/2020-10-reveals-mouth-primary-source-covid-.html

Sample quote

In the study, researchers report preliminary results from a clinical trial of 40 subjects with COVID-19 which showed sloughed epithelial cells lining the mouth can be infected with SARS-CoV-2, the coronavirus that causes COVID-19. The amount of virus in patient saliva was positively correlated with taste and smell changes, according to the study.

Relying on oral cell identity maps, researchers also looked at where in the mouth the virus infects. They surveyed oral tissues with the highest levels of ACE2, the receptor that helps coronavirus grab and invade human cells.

Based on ACE2 expression and analysis of cadaver tissue, the most likely sites of infection in the mouth are the salivary glands, tongue and tonsil, the study showed.

The findings provide more evidence of the role of saliva in COVID-19. COVID-19 infection, specifically in the mouth, can allow the virus to spread internally and to others as the infected person breathes, speaks and coughs.

End quote

Re: The official Coronavirus thread [Re: 360view] #2838501
10/28/20 07:39 PM
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Originally Posted by 360view
Covid-19 antibodies last at least 5 months

https://medicalxpress.com/news/2020-10-people-mount-strong-antibody-response.html

Sample quote


"While some reports have come out saying antibodies to this virus go away quickly, we have found just the opposite—that more than 90 percent of people who were mildly or moderately ill produce an antibody response strong enough to neutralize the virus, and the response is maintained for many months," said Florian Krammer, Ph.D., Professor of Vaccinology at the Icahn School of Medicine at Mount Sinai and a senior author of the paper. "Uncovering the robustness of the antibody response to SARS-CoV-2, including its longevity and neutralizing effects, is critically important to enabling us to effectively monitor seroprevalence in communities and to determining the duration and levels of antibody that protect us from reinfection. This is essential for effective vaccine development."

Study findings are based on a dataset of 30,082 individuals, who were screened within the Mount Sinai Health System between March and October, 2020.

End quote


So that begs the question, if a recovered COVID patient donates antibody rich plasma, do the donated antibodies get naturally replaced for the 5? months mentioned above or is the donor now only have say 4 months implied protection?


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