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Re: The official Coronavirus thread [Re: 360view] #2819283
09/10/20 11:24 AM
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Re: The official Coronavirus thread [Re: 360view] #2819356
09/10/20 02:07 PM
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State of Indiana data: Covid-19 hundreds of times more deadly for those over age 60 than those under age 40

https://medicalxpress.com/news/2020-09-coronavirus-hundreds-deadly-people.html

Sample quote

The overall infection fatality ratio among community-dwelling people in Indiana was 0.26%, or one death for every 385 people infected. Age, more than race or sex, was the biggest factor affecting the death rate.

For people 60 or over, one in every 58 infections resulted in death, an IFR of 1.7%. For comparison, the IFR from influenza in the U.S. among people over 65 years is 0.8%. COVID-19 is approximately 2.5 times more deadly than the flu in this age group.

Risk drops off as age decreases. For middle-aged adults between 40 and 59 years old, the IFR was 0.12% – or one death for every 833 infections.

And for infected people under 40, death was uncommon at only about one in 10,000—an IFR of 0.01%.

While age was the strongest factor affecting the death rate, racial differences were notable too. Non-white Indiana residents across all age groups had a three-times higher risk of death if they became infected—an IFR of 0.59% – compared to white residents—0.18% IFR.

End quote

Re: The official Coronavirus thread [Re: 360view] #2819402
09/10/20 04:06 PM
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$3,000,000 prize to guy whose computer software programs pioneered efforts to custom design proteins to fight diseases like Covid-19

https://techcrunch.com/2020/09/10/3...gning-molecules-to-could-fight-covid-19/

Re: The official Coronavirus thread [Re: 360view] #2819604
09/11/20 07:49 AM
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Aussies disclose a potential key finding that
Covid-19 virus has a “trick” that Influenza virus does not...Covid-19 somehow keeps Killer T-cells from multiplying up to fight the infection.

https://medicalxpress.com/news/2020-09-immune-cell-responses-covid-patients.html

Sample quote

What we found is those key immune cells weren't stimulated optimally for rapid proliferation and expansion to fight SAR-CoV-2," Ms Habel said.

"The magnitude of the CD8 killer T cells was only five times higher than those of the naïve immune cells. To give that perspective, it's 10 times lower than what we see during an influenza or glandular fever response."

In addition to magnitude, the team also looked at the activation profile of these immune cells and found that not only was activation poor, but in some cases these cells remained largely naïve, as if they hadn't been exposed to the virus at all.

End quote

Re: The official Coronavirus thread [Re: 360view] #2819607
09/11/20 08:01 AM
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Feeling old?
A molecule called CD47 that cells put on their surfaces as a “Do Not Eat Me” signal may have a lot to do with poor functioning in old age.

https://medicalxpress.com/news/2020-09-key-minimizing-health-aging.html

The Covid-19 virus may also use a trick of using CD47 to hide from the immune system.

https://medicalxpress.com/news/2020-06-nih-cd47-infectious-diseases-immunotherapy.html

Sample quote

NIH investigators and colleagues have discovered that when the immune system first responds to infectious agents such as viruses or bacteria, a natural brake on the response prevents overactivation. Their new study in mBio describes this brake and the way pathogens such as SARS-CoV-2, the virus that causes COVID-19, turn it on. Their finding provides a potential target for an immunotherapy that might be applied to a wide range of infectious diseases.

When a cell senses an infectious agent with molecules called pathogen recognition receptors, part of its response is to increase cell surface expression of a molecule called CD47, otherwise known as the "don't eat me" signal. Increased CD47 expression dampens the ability of cells called macrophages, the immune system's first responders, to engulf infected cells and further stimulate the immune response. Upregulation of CD47 on cells was observed for diverse types of infections including those caused by mouse retroviruses, lymphocytic choriomeningitis virus, LaCrosse virus, SARS CoV-2, and by the bacteria Borrelia burgdorferi and Salmonella enterica typhi.

End quote

Re: The official Coronavirus thread [Re: 360view] #2819701
09/11/20 01:18 PM
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Value of ten minute breaks studied

https://medicalxpress.com/news/2020-09-ten-minutes-massage-rest-body.html

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Even ten minutes of simple rest increased relaxation, albeit to a lesser degree than massage. The findings, reported on 8 September 2020 in the journal Scientific Reports, provide the first indication that short-term treatments can robustly reduce stress on a psychological and physiological level by boosting the body's principal engine for relaxation—the parasympathetic nervous system (PNS).

End quote

Re: The official Coronavirus thread [Re: 360view] #2819703
09/11/20 01:23 PM
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Singapore claims to have created synthetic antibodies against Covid-19 and will partner with Japanese drug companies to quickly market them

https://medicalxpress.com/news/2020-09-therapeutic-modality-coronavirus.html

Sample quote

Over the last two decades, the evolution of sophisticated technologies have enabled drug developers to harness antibodies' exquisite target-binding properties, turning them into a safe and reliable therapeutic modality. There are already more than 80 approved antibody drugs on the market, including several blockbusters for treating cancer and inflammatory conditions.

Natural immune systems are a rich source of antibody-producing cells that protect us from environmental hazards. This immune landscape is incredibly vast and complex; it has been estimated that humans make around ten billion different antibodies, each with the ability to bind to a specific antigen on a disease-causing agent.

End quote

Re: The official Coronavirus thread [Re: 360view] #2819704
09/11/20 01:26 PM
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USA Covid-19 deaths are declining, after two prior peaks

https://medicalxpress.com/news/2020-09-daily-virus-deaths-decline-trend.html

Sample quote

The U.S. has seen two distinct peaks in daily deaths. The nation's summertime surge crested at about half the size of the first deadly wave in April.

Deaths first peaked on April 24 at an average of 2,240 each day as the disease romped through the dense cities of the Northeast.
Then, over the summer, outbreaks in Texas, California and Florida drove daily deaths to a second peak of 1,138 on Aug. 1.

Some states—Florida, Georgia, Mississippi, Nevada and California—suffered more deaths during the summer wave than during their first milder run-in with the virus in the spring. Others—Michigan, Pennsylvania, Maryland and Colorado—definitely saw two spikes in infections but suffered fewer deaths the second time around.

Now about 700 Americans are dying of the virus each day.
That's down about 25% from two weeks ago but still not low enough to match the early July low of about 500 daily deaths, according to an Associated Press analysis of data compiled by Johns Hopkins University.

End quote

Re: The official Coronavirus thread [Re: 360view] #2819899
09/12/20 07:15 AM
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The Peoples Pharmacy podcast has done a second 1 hour interview with Dr. Ralph Baric “The coronavirus hunter” at the University of North Carolina who has researched them for over 30 years.

I recommend it.

https://www.peoplespharmacy.com/articles/show-1226-the-coronavirus-hunter-gives-you-an-update

Dr Baric thinks it is now certain that you can get re-infected with Covid-19.

Dr Baric believes the Moderna and other vaccines are coming along well.

Re: The official Coronavirus thread [Re: 360view] #2820267
09/13/20 03:07 PM
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With the passage of time,
Sweden’s different policy toward Covid-19 virus looks more defendable.

https://www.dailymail.co.uk/news/article-8722051/How-comeback-kid-Sweden-got-laugh-coronavirus.html

Sample quote

However, the situation has totally reversed in three months since then, with infections surging in much of Europe but reaching record low levels in Sweden.

Sweden announced only 7,131 new cases in the month of August, down from 11,971 in July and a far higher figure of 30,909 in June.

By contrast, cases quadrupled from July to August in Spain and France, and more than doubled in Germany and Italy, while Britain this week tightened restrictions after a rise in cases.

The highest infection rates in Western Europe are now in Spain (200 cases per million) and France (118), while Britain is on 37 with Sweden well below them on 17.

Sweden's current figure is lower than in Norway (19) and Denmark (38), with Finland the lowest of the four mainland Nordic countries on seven cases per million.

Schools re-opened in Sweden mid-August and health officials say they do not expect a large resurgence of the virus in the coming weeks.

On Tuesday, Sweden announced that it had carried out a record number of tests last week with only 1.2 per cent coming back positive - the lowest rate since the crisis began.

At the peak of the crisis in the spring, 19 per cent of of tests - nearly one in five - were coming back positive in some weeks.
...snip...
Shops and restaurants remained open with social distancing rules, while most schools stayed open and the rate of infection among children was no higher than in Finland where classrooms closed, officials said.

As Europe edged out of lockdown, Sweden continued to forge its own path by playing down the use of face masks as other countries made them mandatory.

Tegnel has said that masks have little proven effect and could lead to a false sense of security among wearers, and they are not required on public transport.

By contrast, Finland now recommends wearing masks in public places, Norway advises it on Oslo public transport, while Denmark has made it mandatory on all public transport and in taxis.

End quote

Re: The official Coronavirus thread [Re: 360view] #2820307
09/13/20 04:45 PM
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Checking people’s temperatures not a “magic bullet” for detecting Covid-19

https://www.nytimes.com/2020/09/13/health/covid-fever-checks-dining.html

Sample quote

“You are maximally infectious before you exhibit symptoms, if you exhibit any symptoms at all,” Dr. Paltiel said. “You can be exposed and incubating the virus, and be beginning to shed massive amounts of transmissible virus and be a superspreader, without actually exhibiting any symptoms like a fever.”

Temperature checks will do nothing to stop these “ticking time bombs,” he said. “It’s a bad idea.”

Instead, he said, restaurants should push for access to rapid turnaround, point-of-care tests for patrons.

Interestingly, even seriously ill coronavirus patients who need medical attention don’t always have a temperature. Of nearly 6,000 patients in the New York area who were so sick last spring that they were admitted to Northwell Health hospitals, only 30 percent were febrile when they came in, according to a study by Dr. McGinn that was published in the Journal of the American Medical Association.

The trend is consistent with earlier reports, including a study from China that looked at more than 1,000 patients admitted to 552 hospitals through the end of January. The study, published in the New England Journal of Medicine, reported that only 44 percent of the patients had an elevated temperature when they were admitted, though most (88 percent) developed a fever during the course of their hospital stay.

In July, the C.D.C. quietly updated its guidance to businesses, acknowledging that symptom and temperature checks “will not be completely effective” because asymptomatic individuals and those with vague symptoms will pass the screenings.

End quote

Re: The official Coronavirus thread [Re: 360view] #2820649
09/14/20 01:50 PM
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U of Pittsburg finds tiny antibody that can neutralize Covid-19

https://medicalxpress.com/news/2020-09-tiny-antibody-component-highly-effective.html

Re: The official Coronavirus thread [Re: 360view] #2820655
09/14/20 02:03 PM
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Washington University School of Medicine in St. Louis to study whether the MMR vaccine can either prevent Covid-19 infection or make the illness less severe by giving the shot to 30,000 volunteers.

https://medicalxpress.com/news/2020-09-common-vaccine-kids-covid-adults.html

Sample quote

That's because the MMR vaccine carries small amounts of live, weakened viruses; and there are similarities between those viruses and the new coronavirus. They have the similar proteins on their surfaces that are involved in infecting cells in the body.

Researchers think that young antibodies made in response to the MMR vaccine may recognize and fight the coronavirus.

"This type of vaccine appears to strengthen the body's immune response to infections in general, not just to the viruses in that particular vaccine," said one of the collaborative's principal investigators, Dr. Michael Avidan, the anesthesiology department chair at Washington U.

End quote

Re: The official Coronavirus thread [Re: 360view] #2821045
09/15/20 11:27 AM
09/15/20 11:27 AM
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Originally Posted by 360view
Speculative theory that wearing a mask allows through such a small amount of virus in that it acts somewhat like a vaccine....

https://medicalxpress.com/news/2020-09-mask-kind-vaccine-covid-.html

Sample quote

More recently, studies conducted in hamsters seem to show that "higher doses of administered virus led to more severe manifestations of COVID-19," Gandhi and Rutherford wrote. And when the hamsters were protected with simulated masking, they "were less likely to get infected, and if they did get infected, they either were asymptomatic or had milder symptoms than unmasked hamsters," the experts noted.

For ethical reasons, similar trials in humans haven't been conducted. But population studies seem to support the "mask as vaccine" theory. For example, the U.S. Centers for Disease Control and Prevention reported that by mid-July about 40% of coronavirus infections were asymptomatic, but in areas of the United States where mask wearing was very prevalent, that number rose to 80%.

In early outbreaks of SARS-CoV-2 infections on cruise ships,
before the widespread use of face masks,
the rate of cases with no symptoms was about 20%, Gandhi and Rutherford noted.
But in an outbreak on one Argentinian cruise ship where face masks were mandated for passengers and crew, the rate of asymptomatic cases rose sharply, to 81%.

Finally, in two recent outbreaks in U.S. food-processing plants where workers were told to wear masks, 95% of cases of coronavirus infections were asymptomatic, and the remaining 5% experienced only mild-to-moderate symptoms, the two experts said.

End quote


Read this as well.
I like they backed it up with some examples. The one in the article I read was a cruiseship where I believe 80% of occupants were asymptomatic as they were wearing masks.

Last edited by MONC; 09/15/20 11:27 AM.

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Re: The official Coronavirus thread [Re: 360view] #2821347
09/16/20 12:25 AM
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Sample quote

“You are maximally infectious before you exhibit symptoms, if you exhibit any symptoms at all,” Dr. Paltiel said. “You can be exposed and incubating the virus, and be beginning to shed massive amounts of transmissible virus and be a superspreader, without actually exhibiting any symptoms like a fever.”


Quote
Well so much for all that temp checking going on. Seems they need to come up with a 5min. oral, or even rectal one, to get this mess REALLY under control.

Re: The official Coronavirus thread [Re: 360view] #2821381
09/16/20 06:52 AM
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As reported in a much earlier post,
combining a
temperature check
with a “sniff test”
doubles the chance of spotting a Covid-19 infected person.

By “sniff test” they mean asking someone to sniff the odor coming from substance they cannot see, and correctly identifying it.

Peanut butter, mustard, strawberry jam, etc
can serve as the unknown odor to be identified.

About 30% will show a fever,
another 30% will have a loss of smell,
some will have both however.

Adding the check:
is there a “dry cough”
is another thing that should be a warning sign.

None of the 3 above tests approaches the accuracy of a 10 minute Saliva Test for Covid-19.

The Saliva test is less accurate than the Nasal Swab test that takes a long time.

Re: The official Coronavirus thread [Re: 360view] #2821516
09/16/20 11:41 AM
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Stroke is often the first “presenting symptom” of Covid-19 infection in those under age 50.

https://medicalxpress.com/news/2020-09-symptom-younger-patients-covid-.html

Sample quote

The researchers reported that in patients younger than 50, nearly 50 percent had no other visible symptoms of the virus at the time of stroke onset. They also found that the interplay of older age, other chronic conditions and the severity of COVID-19 respiratory symptoms are associated with an extremely elevated risk of death.

"One of the most eye-opening findings of this study is that for patients under 50 years old, many were totally asymptomatic when they had a stroke related to COVID-19. This means that for these patients, the stroke was their first symptom of the disease," said Sposato, professor and the Kathleen and Dr. Henry Barnett Chair in Stroke Research at Western's Schulich School of Medicine & Dentistry, and scientist at Lawson.

Sposato said understanding the interplay between COVID-19 and stroke is important for treatment planning, especially in areas where COVID-19 is actively circulating in the community.

"The take-home message here for health care providers is that if you are seeing a patient with a stroke, particularly in those under 50 years old with large clots, you need to think of COVID-19 as a potential cause even in the absence of respiratory symptoms," said Dr. Sposato.

End quote

Re: The official Coronavirus thread [Re: 360view] #2821539
09/16/20 12:38 PM
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Eli Lilly Inc. monoclonal antibody against Covid-19 shows promise in 400+ person trial

https://medicalxpress.com/news/2020-09-drug-severe-covid.html

Sample quote

In the trial, 452 newly diagnosed COVID patients received the monoclonal antibody or a placebo infusion. Some 1.7 percent of those who got the drug were hospitalized, compared with 6 percent of those who received a placebo— a 72 percent reduction in risk, Eli Lilly said.

At the same time, blood levels of the coronavirus plummeted among those who received the drug, and their symptoms were fewer and milder, the Times reported.

This is the first treatment aimed at patients who are not already seriously ill and hospitalized, the newspaper added.

Dr. Myron Cohen, director of the Institute for Global Health and Infectious Diseases at the University of North Carolina at Chapel Hill, told the Times he was impressed by the findings.

"It's exciting," said Cohen, who was not involved in the study. The trial appears to be rigorous, and the results are "really compelling," he added. Other monoclonal antibody drugs to combat the coronavirus are in development, he noted.

End quote

Re: The official Coronavirus thread [Re: 360view] #2821556
09/16/20 01:05 PM
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Covid-19 deaths in America have been higher because citizens have poor health habits

https://www.forbes.com/sites/andrew...d-the-way-for-covid-deaths/#6938906f3768

Re: The official Coronavirus thread [Re: 360view] #2821665
09/16/20 05:39 PM
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More evidence T-cells lead the fight against Covid-19,
and lower levels of T-cells in those over age 60 cause more severe disease.

https://medicalxpress.com/news/2020-09-cells-sars-cov-covid-disease-severity.html

Sample quote

"Our observations could also explain why older COVID-19 patients are much more vulnerable to the disease," says senior author Shane Crotty, Ph.D., who co-led the study with Alessandro Sette, Dr. Biol.Sci., both professors in LJI's Center for Infectious Disease and Vaccine Research. "With increasing age, the reservoir of T cells that can be activated against a specific virus declines and the body's immune response becomes less coordinated, which looks to be one factor making older people drastically more susceptible to severe or fatal COVID-19."

Adds Sette, "What we didn't see was any evidence that T cells contribute to a cytokine storm, which is more likely mediated by the innate immune system."
...snip...

The effect was magnified when the researchers broke down the dataset by age. "People over the age of 65 were much more likely to have poor T cell responses, and a poorly coordinated immune response, and thus have much more severe or fatal COVID-19," says Crotty. "Thus, part of the massive susceptibility of the elderly to COVID-19 appears to be a weak adaptive immune response, which may be because of fewer naïve T cells in the elderly."

Naïve T cells are inexperienced T cells that have not met their viral match yet and are waiting to be called up. As we age, the immune system's supply of deployable naïve T cells dwindles and fewer cells are available to be activated to respond to a new virus. "This could either lead to a delayed adaptive immune response that is unable to control a virus until it is too late to limit disease severity or the magnitude of the response is insufficient," says Moderbacher.

In line with what other research teams had found before, antibodies don't seem to play an important role in controlling acute COVID-19. Instead, T cells and helper T cells in particular are associated with protective immune responses. "This was perplexing to many people," says Crotty, "but controlling a primary infection is not the same as vaccine-induced immunity, where the adaptive immune system is ready to pounce at time zero."

End quote

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