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Re: The official Coronavirus thread [Re: 360view] #2800722
07/24/20 06:34 PM
07/24/20 06:34 PM
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International team identifies 21 more existing drugs that might treat Covid-19

https://medicalxpress.com/news/2020-07-drugs-covid-.html

Sample quote

"Based on our current analysis,
clofazimine,
hanfangchin A,
apilimod and
ONO 5334
represent the best near-term options for an effective COVID-19 treatment," says Chanda. "While some of these drugs are currently in clinical trials for COVID-19, we believe it's important to pursue additional drug candidates so we have multiple therapeutic options if SARS-CoV-2 becomes drug resistant."

Screening one of the world's largest drug libraries

The drugs were first identified by high-throughput screening of more than 12,000 drugs from the ReFRAME drug repurposing collection—the most comprehensive drug repurposing collection of compounds that have been approved by the FDA for other diseases or that have been tested extensively for human safety.
End quote

Re: The official Coronavirus thread [Re: 360view] #2800749
07/24/20 08:13 PM
07/24/20 08:13 PM
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Question on wearing a mask?
Here in Ohio the Gov. made it mandatory to wear a mask inside any building that is not a residence and out doors if you can't social distance 6ft. I think New York might have similar mandate.
I watch the local news and national morning shows like GMA and the Today show and the the newscasters inside the studio never wear mask?? The reporters outside and clearly not near anyone have masks on??
Why are the newscasters taking such risks?? Oh I know they are exempt, for the people that have to read lips that watch the show??
Please explain the rational?

Re: The official Coronavirus thread [Re: 360view] #2800824
07/24/20 11:14 PM
07/24/20 11:14 PM
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Originally Posted by 360view
High levels of the hormone Leptin affects immune response to covid-19
Obesity increases Leptin levels.

https://medicalxpress.com/news/2020-07-obesity-common-covid-patients.html

Sample quote

Elevated leptin levels hamper the body's ability to fight off infections, in the lungs and elsewhere, Dr. Rebello said. High leptin levels promote a low-grade systemic inflammatory state.

"If you have obesity, there are a number of underlying health issues that make it more difficult for you to fight off a COVID-19 infection," said John Kirwan, Ph.D., Pennington Biomedical Executive Director and a co-author of the review. "Your entire body, including your lungs, may be inflamed. Your immune response is likely compromised, and your lung capacity reduced.

"Add in a virus that further weakens the body's ability to fight infection, that can limit the body's ability to control lung inflammation, and you have the recipe for disaster."

End quote


Anecdotally, it seems to me a very high percentage of the pics on TV of those who have succumbed to COVID, are notably obese from day one of this pandemic. And in full disclosure, I would also fall into that category.


Reality check, that half the population is smarter then 50% of the people and it's a constantly contested fact.
Re: The official Coronavirus thread [Re: jcc] #2800853
07/25/20 02:49 AM
07/25/20 02:49 AM
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Originally Posted by jcc
Originally Posted by 360view
High levels of the hormone Leptin affects immune response to covid-19
Obesity increases Leptin levels.

https://medicalxpress.com/news/2020-07-obesity-common-covid-patients.html

Sample quote

Elevated leptin levels hamper the body's ability to fight off infections, in the lungs and elsewhere, Dr. Rebello said. High leptin levels promote a low-grade systemic inflammatory state.

"If you have obesity, there are a number of underlying health issues that make it more difficult for you to fight off a COVID-19 infection," said John Kirwan, Ph.D., Pennington Biomedical Executive Director and a co-author of the review. "Your entire body, including your lungs, may be inflamed. Your immune response is likely compromised, and your lung capacity reduced.

"Add in a virus that further weakens the body's ability to fight infection, that can limit the body's ability to control lung inflammation, and you have the recipe for disaster."

End quote


Anecdotally, it seems to me a very high percentage of the pics on TV of those who have succumbed to COVID, are notably obese from day one of this pandemic. And in full disclosure, I would also fall into that category.


Quote
With the obesity rate in this country & our lack of a "real" active lifestyle, the death rate isn't that surprising wrt covid. Unless you consider active being "banging" away at keypads & touch screens.

Re: The official Coronavirus thread [Re: nss guy] #2800868
07/25/20 07:33 AM
07/25/20 07:33 AM
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Originally Posted by nss guy
Question on wearing a mask?
Here in Ohio the Gov. made it mandatory to wear a mask inside any building that is not a residence and out doors if you can't social distance 6ft. I think New York might have similar mandate.
I watch the local news and national morning shows like GMA and the Today show and the the newscasters inside the studio never wear mask?? The reporters outside and clearly not near anyone have masks on??
Why are the newscasters taking such risks?? Oh I know they are exempt, for the people that have to read lips that watch the show??
Please explain the rational?


I cannot explain that,
but “the press” is given special freedom in the text of the 1st Amendment,
and the 14th Amendment says that no state can deny its citizens a right they have under the US Constitution,
so those reporters do have special legal protection for many behaviors.

Maybe we all should publish a newspaper,
and make a video newscast,
say once a year at Christmas?
smile

Every citizen a militia member...... and every citizen a press publisher.

Re: The official Coronavirus thread [Re: jcc] #2800869
07/25/20 07:40 AM
07/25/20 07:40 AM
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Anyone thinking of a “scientific way”
to lose some fat
should watch Dr Michael Mosley’s one hour BBC show:
Eat, Fast, and live longer.

Although it is a BBC program,
most of it takes place in the USA.

https://www.dailymotion.com/video/x370lox

Re: The official Coronavirus thread [Re: 360view] #2801641
07/27/20 09:59 AM
07/27/20 09:59 AM
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Monday Wall Street Journal has a front page article
“Covid-19 Vaccines’ Duration Is Uncertain”.

Surveys of recovered Covid-19 patients mostly show that antibodies begin to fade as early as 90 days.

T-cell duration is unknown,
but recovered SARS coronavirus patients from year 2002 still have T-cells that can not only kill SARS infected cells, but many can further kill today’s Covid-19 virus infected cells as well.

Re: The official Coronavirus thread [Re: 360view] #2801701
07/27/20 12:27 PM
07/27/20 12:27 PM
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Originally Posted by 360view

but recovered SARS coronavirus patients from year 2002 still have T-cells that can not only kill SARS infected cells, but many can further kill today’s Covid-19 virus infected cells as well.




If that is the case, why was China's Covid19 infection/death rate so high? seeing they have had several SARS type outbreaks over the last 10-15 years....

Re: The official Coronavirus thread [Re: DAYCLONA] #2801729
07/27/20 01:43 PM
07/27/20 01:43 PM
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Maybe because they have a population of 1.4 Billion, the previous SARs infections were not universal to the nation, and they shutdown promptly enough?

Last edited by jcc; 07/27/20 01:45 PM.

Reality check, that half the population is smarter then 50% of the people and it's a constantly contested fact.
Re: The official Coronavirus thread [Re: DAYCLONA] #2801791
07/27/20 04:47 PM
07/27/20 04:47 PM
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Originally Posted by DAYCLONA
Originally Posted by 360view

but recovered SARS coronavirus patients from year 2002 still have T-cells that can not only kill SARS infected cells, but many can further kill today’s Covid-19 virus infected cells as well.




If that is the case, why was China's Covid19 infection/death rate so high? seeing they have had several SARS type outbreaks over the last 10-15 years....


In 2012 China had an virus outbreak at a mine in Yunnan province. It killed three male miners and sickened “several dozen” miner family members. This coronavirus was traced to “Horseshoe Bats” in abandoned parts of the mine, and was 99.8% similar to Covid-19.

China did not develop a vaccine despite the virus being proved fatal to humans.

China did share a sample of the virus with researchers from India, who decoded the RNA and published the gene sequence in a medical journal.

This was in a previous post in this thread by a long article in the Wall Street Journal by Matt Ridley.

Someone reading this post may have previously had one or more of the 4 circulating coronaviruses that are lumped iwith the many rhino and adeno family viruses called as a group “common colds.” This previous Infection may have resulted in having antibodies or T-cells that fight Covid-19 at least partially.

Re: The official Coronavirus thread [Re: 360view] #2801795
07/27/20 05:02 PM
07/27/20 05:02 PM
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Re: The official Coronavirus thread [Re: 360view] #2801801
07/27/20 05:10 PM
07/27/20 05:10 PM
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Starting this month,
and adding a new vaccine’s trial each month,
a group of 30,000 younger USA citizen volunteers will get a trial vaccine for Covid-19.
Some vaccines will require two doses.

150,000 in total have expressed interest in being in a vaccine trial.

https://medicalxpress.com/news/2020-07-experimental-covid-vaccine-biggest.html

Sample quote

After volunteers get two doses a month apart, scientists will closely track which group experiences more infections as they go about their daily routines, especially in areas where the virus is spreading unchecked.

The answer probably won't come until November or December, cautioned Dr. Anthony Fauci, NIH's infectious-diseases chief.

Among many questions the study may answer:
How much protection does just one dose offer compared with the two scientists think are needed?
If it works, will it protect against severe disease or block infection entirely?

Don't expect a vaccine as strong as the measles vaccine, which prevents about 97% of measles infections, Fauci said, adding he would be happy with a COVID-19 vaccine that's 60% effective.

Several other vaccines made by China and by Britain's Oxford University began smaller final-stage tests in Brazil and other hard-hit countries earlier this month. But the U.S. requires its own tests of any vaccine that might be used in the country.

End quote

Re: The official Coronavirus thread [Re: 360view] #2801803
07/27/20 05:18 PM
07/27/20 05:18 PM
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Young medical student creates dataset that indicates
Influenza vaccines and Pneumococci vaccines
have some measurable protective effect
against Alzheimer’s disease.

https://medicalxpress.com/news/2020-07-flu-pneumonia-vaccinations-tied-alzheimer.html

Sample quote

Previous research has suggested vaccinations may have a protective factor against cognitive decline, but there have been no large, comprehensive studies focused on the influenza (flu) vaccine and Alzheimer's disease risk, specifically. To address this gap, Albert Amran, a medical student at McGovern Medical School at The University of Texas Health Science Center at Houston, and team, investigated a large American health record dataset (n=9,066).

Amran and team found having one flu vaccination was associated with a lower prevalence of Alzheimer's (odds ratio 0.83, p<0.0001), and among vaccinated patients receiving the flu vaccine more frequently was associated with an even lower prevalence of Alzheimer's (odds ratio 0.87, p=0.0342). Thus, people that consistently got their annual flu shot had a lower risk of Alzheimer's. This translated to an almost 6% reduced risk of Alzheimer's disease for patients between the ages of 75-84 for 16 years.

The researchers found the protective association between the flu vaccine and the risk of Alzheimer's was strongest for those who received their first vaccine at a younger age—for example, the people who received their first documented flu shot at age 60 benefitted more than those who received their first flu shot at age 70.

"Our study suggests that regular use of a very accessible and relatively cheap intervention—the flu shot—may significantly reduce risk of Alzheimer's dementia," Amran said. "More research is needed to explore the biological mechanism for this effect—why and how it works in the body—which is important as we explore effective preventive therapies for Alzheimer's."

Pneumonia Vaccine May Reduce Alzheimer's Risk Later in Life

Repurposing of existing vaccines may be a promising approach to Alzheimer's disease prevention. Svetlana Ukraintseva, Ph.D., Associate Research Professor in the Biodemography of Aging Research Unit (BARU) at Duke University Social Science Research Institute, and team, investigated associations between pneumococcal vaccination, with and without an accompanying seasonal flu shot, and the risk of Alzheimer's disease among 5,146 participants age 65+ from the Cardiovascular Health Study. The team also took into account a known genetic risk factor for Alzheimer's—the rs2075650 G allele in the TOMM40 gene.

The researchers found that pneumococcal vaccination between ages 65-75 reduced risk of developing Alzheimer's by 25-30% after adjusting for sex, race, birth cohort, education, smoking, and number of G alleles. The largest reduction in the risk of Alzheimer's (up to 40%) was observed among people vaccinated against pneumonia who were non-carriers of the risk gene. Total number of vaccinations against pneumonia and the flu between ages 65 and 75 was also associated with a lower risk of Alzheimer's; however, the effect was not evident for the flu shot alone.

End quote

Re: The official Coronavirus thread [Re: 360view] #2801808
07/27/20 05:27 PM
07/27/20 05:27 PM
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Small percentage of dogs and cats got infected with Covid-19 in Italy

https://medicalxpress.com/news/2020-07-evidence-exposure-sars-cov-cats-dogs.html

Re: The official Coronavirus thread [Re: 360view] #2801813
07/27/20 05:31 PM
07/27/20 05:31 PM
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In Canada most of the increase in Covid-19 infections are in those under age 39

https://medicalxpress.com/news/2020-07-young-adults-majority-virus-cases.html

(Probably the same in USA but records harder to compile)

Re: The official Coronavirus thread [Re: 360view] #2801947
07/27/20 11:48 PM
07/27/20 11:48 PM
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Quote
MLB's Worst Nightmare Is Here. They Should Have Seen It Coming
The league is grappling with a widespread COVID-19 outbreak on the Miami Marlins.


https://www.si.com/mlb/2020/07/27/miami-marlins-covid-outbreak-testing

It will be informative to see what the results of the Phillies' tests are.

Quote
And here we have it, the least surprising possible outcome of MLB’s decision to fly some 1,500 people around the country, from one coronavirus hotspot to another, buttressed by a hope and a prayer and instructions not to spit, in service of playing baseball: They have to stop playing baseball.

Four Marlins players had tested positive for COVID-19 by Sunday afternoon. As of Monday morning, that count was reportedly at least 11 players and two coaches. Miami’s scheduled Monday night home opener against the Orioles has been postponed.

But the Marlins played three games against the Phillies this weekend. Last week, they played two exhibition games in Atlanta against the Braves. It’s impossible to know how far the infected droplets sprayed. Both of the Braves’ primary catchers, Tyler Flowers and Travis d’Arnaud, missed the weekend series against the Mets after they exhibited COVID-19 symptoms. The Phillies players and coaches are waiting on test results; The Athletic reported that their entire visiting clubhouse staff has been quarantined. The Yankees-Phillies game on Monday has been postponed. The season is four days old.

Re: The official Coronavirus thread [Re: 360view] #2802057
07/28/20 09:53 AM
07/28/20 09:53 AM
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Originally Posted by 360view
Young medical student creates dataset that indicates
Influenza vaccines and Pneumococci vaccines
have some measurable protective effect
against Alzheimer’s disease.

https://medicalxpress.com/news/2020-07-flu-pneumonia-vaccinations-tied-alzheimer.html

Sample quote

Previous research has suggested vaccinations may have a protective factor against cognitive decline, but there have been no large, comprehensive studies focused on the influenza (flu) vaccine and Alzheimer's disease risk, specifically. To address this gap, Albert Amran, a medical student at McGovern Medical School at The University of Texas Health Science Center at Houston, and team, investigated a large American health record dataset (n=9,066).

Amran and team found having one flu vaccination was associated with a lower prevalence of Alzheimer's (odds ratio 0.83, p<0.0001), and among vaccinated patients receiving the flu vaccine more frequently was associated with an even lower prevalence of Alzheimer's (odds ratio 0.87, p=0.0342). Thus, people that consistently got their annual flu shot had a lower risk of Alzheimer's. This translated to an almost 6% reduced risk of Alzheimer's disease for patients between the ages of 75-84 for 16 years.

The researchers found the protective association between the flu vaccine and the risk of Alzheimer's was strongest for those who received their first vaccine at a younger age—for example, the people who received their first documented flu shot at age 60 benefitted more than those who received their first flu shot at age 70.

"Our study suggests that regular use of a very accessible and relatively cheap intervention—the flu shot—may significantly reduce risk of Alzheimer's dementia," Amran said. "More research is needed to explore the biological mechanism for this effect—why and how it works in the body—which is important as we explore effective preventive therapies for Alzheimer's."

Pneumonia Vaccine May Reduce Alzheimer's Risk Later in Life

Repurposing of existing vaccines may be a promising approach to Alzheimer's disease prevention. Svetlana Ukraintseva, Ph.D., Associate Research Professor in the Biodemography of Aging Research Unit (BARU) at Duke University Social Science Research Institute, and team, investigated associations between pneumococcal vaccination, with and without an accompanying seasonal flu shot, and the risk of Alzheimer's disease among 5,146 participants age 65+ from the Cardiovascular Health Study. The team also took into account a known genetic risk factor for Alzheimer's—the rs2075650 G allele in the TOMM40 gene.

The researchers found that pneumococcal vaccination between ages 65-75 reduced risk of developing Alzheimer's by 25-30% after adjusting for sex, race, birth cohort, education, smoking, and number of G alleles. The largest reduction in the risk of Alzheimer's (up to 40%) was observed among people vaccinated against pneumonia who were non-carriers of the risk gene. Total number of vaccinations against pneumonia and the flu between ages 65 and 75 was also associated with a lower risk of Alzheimer's; however, the effect was not evident for the flu shot alone.

End quote


That was interesting, and new for me. up

And number wise I believe Alzheimer's will likely effect a much larger population in the US, over a much longer period then COVID will, a slow mental death vs a quicker suffocation check out. eek


Reality check, that half the population is smarter then 50% of the people and it's a constantly contested fact.
Re: The official Coronavirus thread [Re: 360view] #2802096
07/28/20 11:34 AM
07/28/20 11:34 AM
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In Wales a blood drop fast test for Covid-19 developed:

https://medicalxpress.com/news/2020-07-pinprick-blood-covid-.html

Re: The official Coronavirus thread [Re: 360view] #2802103
07/28/20 11:41 AM
07/28/20 11:41 AM
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Maybe tiny individual Covid-19 viruses can float in air,
not just inside droplets,
and tall people may be more at risk:

https://medicalxpress.com/news/2020-07-survey-aerosol-significant-covid-transmission.html

Sample quote
The survey analyzed by a team of data scientists in the UK, Norway and the US is one of the first to examine a wide range of personal and work-related predictors of transmission.

Taking both samples together, being tall more than doubled the probability of having a COVID 19 medical diagnosis or positive test for people over 6ft.

The data in both countries, argue the researchers, could suggest that aerosol transmission is very likely, with taller individuals at higher risk—something that would not be expected if transmission was exclusively through droplets.

And that, they say, is something that would not have been observed if downward droplet transmission was the only transmission mechanism.

Aerosols can accumulate in poorly ventilated areas and are carried by air currents. Droplets, however, are bigger than aerosols and are thought to travel relatively short distances and drop quickly from the air.

Though the paper is yet to be peer reviewed, the authors feel its implications on the debate over aerosol transmission should be made available to the wider community.
End quote

Re: The official Coronavirus thread [Re: 360view] #2802105
07/28/20 11:44 AM
07/28/20 11:44 AM
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