After running open exhaust and tuning the carb for it for many years, I installed a 3" TTI X-pipe with Dynomax Ultra Flo mufflers terminating at the rear end housing. After removing 60 lbs from elsewhere in the car that the extra exhaust system weighed and tuned on the carb a bit more - going leaner actually, the car picked up
at least several hundredths! (Not same day back-to-back, but using detailed record keeping.) So, despite the inconvenience when having to swap transmissions or center sections, the system has remained on the car.
Just like swapping intake manifolds, cams, headers, etc., it depends on the overall package and carb tune-up. A single different part can alter jetting requirements, so only re-tuning & testing to
know the best tune-up for each will provide the best comparison between the part changes.
A 2.5" exhaust system would tend to be a choke-point. Going to open headers or a larger exhaust system will likely change the optimum jet sizes as well as squirters. Just different mufflers can have a similar affect because of backpressure changes. (i.e.: A current set-up is a little on the rich side, so it's not "optimized" or as fast as it could be. A change is made that would require a richer tune-up, but it's already richer than the previous set-up needed. So the results appear better than the should be.-----If the previous set-up was too lean and a change was made that needs richer jetting, then the results of the change would be worse than they should be.)
Carb tuning for each change is not easy and is time consuming. But each combo, as well as tune-up, is different and that explains the wide variety of ET changes when adding, changing or removing an exhaust system - as well as other parts.