Al, 6lbs of boost is 6lbs of boost.
On gauge yes, performance no. Air expands as its temp goes up. What might only be 4 psi (theoretical) can easily become 6 psi or more on the gauge do to intake charge temp. Boost at low intake temps means denser air, thus more power at the same gauge reading. And yes E85 for street or even mild race boosted motors is the ticket.
Doug
Exactly. 6 psi at 220*F air temp is much less desirable than 6 psi @ 120*F air temp. You have to run less timing if you're octane limited the warmer the intake charge is, and even without that the colder air @ 6 psi is denser so it would make more power regardless.
Also worth mentioning, the comparison of your roots blower car to your son's car brings up another good point. Even with the same engine, same intake temp and same boost, the turbo car is going to make more power because a roots blower takes significant horsepower to turn. a 700 hp roots blown motor is making more like 850 hp at the pistons, but loses 150 of it to spin the blower over. The turbo engine will lose power from reduced VE but it's not as significant as the mechanical effort to drive a blower.
For timing you may want to ramp it in less aggressively. Cylinder pressures are higher along with the detonation risk at peak torque and below, especially on a supercharged application.