In one of Crane Cams old catalog they recommend setting the lash .006 tighter with a iron block and aluminum heads and .012 tighter with aluminum block and aluminum heads.
I used those recommendation on a blown KB aluminum street Hemi block with a set of Dart water casting aluminum headson a motor I assembled and they prove to be dead on when I rechecked them hot on the dyno after running the motor long enough (20 to 30 minutes at or around 2500 RPM) to get the oil temp. up to 170F
I have seen those settings not work on a wedge motors with Eddy aluminum heads on a 400 iron block
My old pump gas motor with those heads would vary right at .001 looser hot than cold(65 to 70 F shop temps.
I would run the motor driving into town for 20+ minutes and the same amount of time coming back to the shop later and then check the lash hot on one side with the method of when exhaust opens, set the intake and then rotate the motor over clockwise until the intake opens all the way and starts to close a little past BTDC and then set the exhaust
I would start the motor up after doing one side and let it run until I got at least 160+ F water temps agian on the temp guge and then do the other side.
In the morning with the motor cold and at or close to 60F in the shop the valves where tighter by .0005 to .0015