Mark, I've built a few of those magnum motors by now
in my Dakota, I have a stock short block, cam, headers, Edelbrock heads, M1 4bbl intake with 2bbl adapter, and an F&B 58mm TB
the whole thing bolts into my truck like a stock production motor.
You can get what you want easily. Stock computer, wire harness for EFI, use SCT to tune the computer to your CID and cam specs. there are 2 top SCT tune writers I would suggest to you.
but, to answer JUST the question you asked, Yes, there are larger aftermarket 2bbl TBs that bolt on like stock, and use stock sensors. F&B is probably the best you'll find. they offer different sizes too. for a 450hp 408, I would suggest either their 55mm or 58mm TB.