yes LT Dan has a 408 in his 96 Ram...
Up until recently Ive been very happy with it as it now has a broken lifter that totally wiped out my cam and even after doing the autopsy, I cant find a reason why the lifter seized.
Anyway, mine is a 4X2 reg cab short bed so its about the same weight as an extended cab Dakota and I built it back in 2004 (wow has it been 8 years already?) to outrun Lightnings, which were the hot truck at the time and I have no problem doing that. Back then, there werent as many options as there are now and honestly I havent kept up with all the new parts that are available for the 318/360 Magnums now so I can only post about what I built and how it runs.
My intent for my truck is a little different than the OPs in that its mainly for street use as I dont need it to tow anything anymore, although I have pulled my boat with it a few times and brought my Trans Am home on a car trailer from Maryland last summer, it never bogged and never ran hot or anything. An RV cam would work well with a 408 if extra power for towing is your intent.
I have the 2 BBL SMPI M1 intake-I dont particularly care for it for my application but the dual plane wasnt available at the time when I built the engine-go with the DP FI unit thats out now. If I had more cam and/or a lighter vehicle with more gear, it would work better but in a heavy truck it doesnt make the most of the low end torque in a 408.
I was running 64 lb Viper injectors at one point but it was too much. Ford has a 48 lb injector that would be a better street application for a mild engine. At the moment Im actually running the OE 318 12 lb injectors since I was driving it daily to work before I wiped out the cam and wanted better mileage. I put a bigger throttle body on it but honestly I cant remember which one I used. Can I claim old man syndrome at 37?
I have a B&G flashed computer tuned for street/strip use.
My cam specs are:
Comp Cams# 20-744-9
lift=.480/.480
Duration @ .050=206/212
Theres no need to go crazy with a cam and remember since you are planning to keep your EFI to keep the duration short since theres only a short time window that the computer-controlled injectors will fire.
The cylinder heads are basically stock 2001 Dakota R/T units with some port and polish work.
My crank, rods and pistons all came from Mopar and everything was balanced at the machine shop. The pistons are 9.5 MPs. The broken lifters are 1.6 Rhodes units.
I run 3.90 gears and a 2500 rpm converter in a 46RE with a simple shift kit and I have a full, true dual exhaust with 2 cats.
The above combo was good for a best of 13.37 AT 103, pretty good for a 4400 lb pickup truck, it gets 16-18 mpg and I got almost 50,000 miles on it before it broke.