Bought a pair of Quick Fuel E-85 metering blocks at the March Indy cyl. head swap meet in 2017. Calculated a 30% increase in area for all the fuel flowing holes in my carb. and enlarged/jetted them up. Bought local E-85 at the nearby B.P. station. Runs great. No detonation at 9.9 C.R. and 13 lbs. of boost at 20 deg. timing. The only real problem I have is if you let it sit for weeks, the accelerator pump check valve weights under the shooter get "sticky" and the pumps won't work until I remove the shooter and wiggle them while pushing the pump arm. I do drain the system and flush it with gasoline at the end of the year. I am running bare aluminum fuel lines, bare aluminum fuel cell, regular A/N line and fittings. After a cruise/beating session the intake manifold feels to be about room temperature upon arriving back home. For me the benefits more than outweigh the liabilities.

We ain't like that

At this point I was planning on running as close to 15:1 as possible. I want to maintain as minimal a dome as possible while keeping maximum compression. Still waiting on my heads to come back before making any hard decisions. At any rate, I don't feel that there would be much to gain trying to increase compression beyond 15:1.

X2, you're in the zone of diminishing returns for more static CR.

I was told years ago by a pretty sharp engine builder that at about 15.5 compression gains become vitually zero, and more compression just takes more fuel to bandaid problems. That is why my motor is at 15.1/1

That would be true if you had a cylinder head that could actually fill the cylinder. That doesn't really exist in the mopar aftermarket save a Pro stock head. So higher statics always help.